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B Vitamins work so closely with one another that a deficiency in any one B Vitamin can lead to poor functioning of any or all of the others even if they are in good supply

In vivo data statistical analysis Differences in body weight and food intake were assessed using a linear mixed-effects model with body weight or food intake as the response variable, treatment and day as predictor variables with interaction effects, and samples as random effects

Cancer Transl

The step-wise dose increases exist to manage GI adaptation

Indian J Exp Biol

Its very important because not having enough can cause serious health problems