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Dunning S, Ur Rehman A, Tiebosch MH, et al

Influence of the extracellular matrix on cell-intrinsic circadian clocks

INTRODUCTION G protein-coupled receptors (GPCRs) mediate diverse physiological processes through selective modulation of cellular function and thus represent important drug targets (Hauser et al

Aspiration can lead to several serious complications: Aspiration pneumonitis : Chemical injury to lung tissue from acidic gastric contents, causing inflammation, hypoxemia, and potentially acute respiratory distress syndrome (ARDS) [8] [9] Aspiration pneumonia : Bacterial infection resulting from aspirated material Airway obstruction : Particulate matter blocking airways Prolonged mechanical ventilation : Severe cases may require respiratory support Potential for ICU admission and extended hospital stay if severe aspiration occurs Case reports and observational studies have documented instances of unexpected gastric contents found during endoscopy or anesthesia induction in patients taking GLP-1 receptor agonists who had followed standard fasting protocols