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Karl Brandt et al.), helped shape how we view and perform clinical research today

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Limits included changing the amount of savings states can carry over between demonstrations and establishing new rules on spending trend rates used in budget neutrality calculations

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The size of the cohort precluded multivariate analyses, and there was the additional inconvenience that the follow-up period coincided with the advent of the COVID-19 crisis, which hampered proper data gathering and patient surveying