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There are several areas within the brain that abut ventricles and have no blood brain barrier

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This non-traditional screening approach carried the risk that the GLP-1R agonist lead series might remain dependent on the presence of BETP to activate the receptor, and it was unclear at the outset whether we would observe GLP-1R agonism in the absence of BETP

doi: 10.1007/s11695-019-04167-x

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Sometimes the answer is patience