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TAX1BP1 is necessary for clearance of insoluble NCOA4 condensates and ferritin via recruitment of FIP200 [58]

185 Besides, other MTHFD2 inhibitors have been reported, including DS18561882 and LY345899 in a substrate-based manner, and treatments based on them decrease cellular NADPH/NADP + ratio, increase cellular ROS levels, and impair tumorigenesis and metastasis

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Improved intestinal absorption results from enhanced permeation through tight junction modulation, lymphatic targeting via lipid-based systems, receptor-mediated endocytosis, and size-dependent paracellular transport

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