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doi: 10.1113/JP273839 38 WirthR.KdrG.KakukB.MartiG.BagiZ.Szilgyi.et al

Interestingly, assessment of binding properties in a hemi-equilibrium membrane binding assay revealed that OWL-833 had 10-fold higher affinity than PF 06882961 ( Figures 1H & S1G ), suggesting that while the two agonists have similar concentration response profiles in cAMP accumulation ( Figure 1B ), PF 06882961 has higher efficacy for this pathway