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305 In a randomized controlled trial of 24 patients with IBS-D, the bile acid sequestrant colesevelam (Welchol) significantly increased ascending colon emptying time by four hours compared with placebo

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PMID: 25497068

ii) Studies that were original research articles, including randomized controlled trials (RCTs) and protocol studies

POI is thought to be significantly influenced by oxidative stress, which is connected to ovarian ageing and mitochondrial failure 91