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Nijhout, H

J Clin Invest 121:20942101

Semaglutide works through several mechanisms: Appetite regulation : It acts on receptors in the brain's appetite centres, particularly the hypothalamus, reducing hunger and increasing feelings of fullness Gastric emptying : It slows the rate at which food leaves the stomach, prolonging satiety Glucose regulation : It enhances insulin secretion when blood glucose is elevated and suppresses inappropriate glucagon release The medication reaches steady-state concentrations after approximately 45 weeks of regular dosing, with a half-life of about one week

The second-generation anti-androgen drugs such as enzalutamide or abiraterone in standard treatment of advanced prostate cancer combined with ferroptosis activator can further inhibit tumor proliferation [17]

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Therefore, LXR agonists may attenuate statin-induced ALS