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doi: 10.1186/bcr3348 45 AliTKamathSM

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10.1016/j.bios.2013.11.040 65 LiR.LiuJ.LiL.WangH.WengZ.LamS

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IGF-I also binds to the insulin receptor (IR) but with much lower (about 100-fold lower) affinity than to the IGF1R (Pandini et al ., 2002)

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[56] It does this by upregulating phosphorylated IRS-1 and activating pathways (like AMPK/SIRT1) that promote the transport of the GLUT4 glucose transporter to cell membranes in muscle and adipose tissue, thereby increasing overall cellular glucose uptake

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