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After the validation process, the developed PBPK model can be used to assess the impact of the mechanism of action on the pharmacokinetics of various victim drugs.58,156 Conclusion In this review, pharmacokinetics, pharmacokinetic drugdrug interactions (DDIs), and pharmacokinetic modeling approaches of four currently available GLP-1 RAs (exenatide, liraglutide, dulaglutide, and semaglutide) and a dual GLP-1/GIP RA (tirzepatide), are discussed

It is also worth considering that fatigue attributed to GLP-1 therapy may actually reflect underlying conditions such as hypothyroidism, anemia, sleep apnea, or depression, which should be evaluated if tiredness persists