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120 An unexpected phenotype produced by GIPR deficient ob/ob mice was that they lost weight by increasing their energy expenditure, which is surprising as their insulin levels were not significantly altered in comparison to control mice, and therefore their energy expenditure should have been similar to control mice
The other two forms are much rarer
Tirzepatide (Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management
2001 in Endocrinology showed reduced body weight gain with 14-day AOD-9604 in obese (ob/ob) mice and identified the beta-3 adrenergic receptor dependency
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