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One possibility would be that all sirtuins may similarly bind to nucleosomes, probably through their conserved catalytic domain, and thus H3 tails, but not H4 tails, would be located near the catalytic pockets of all the sirtuins

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Caspase-dependent protein degradation is also attenuated by IGF/PI3K/Akt signaling, whereas evidence for an effect on calpain-dependent protein degradation is inconclusive

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However, individual responses vary, and monitoring remains important