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However, the prospective Shanghai Osteoarthritis Cohort study showed that GLP-1RA users with KOA and diabetes exhibited a greater reduction in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total and pain score and a lower occurrence of knee surgery compared to controls

population has filled a GLP-1 prescription, representing roughly 9-15 million individuals across diabetes, weight loss, and cardiovascular indication categories

Drge W, Breitkreutz R

Some authors suggest that it might have limited application due to its variability [24]

No large randomized controlled trial directly compares monotherapy against the combination, and what exists is limited observational data and small case series suggesting an additive effect

The adjusted mean change in lean soft tissue mass (% of total body weight) in the semaglutide group was 5.5% (s.e