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GLP-1 receptor agonists, such as semaglutide, complement this by suppressing appetite, improving insulin sensitivity, and promoting satiety, helping reduce calorie intake naturally
[16] These medications work through multiple complementary mechanisms: they enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release from alpha cells, slow gastric emptying to reduce postprandial glucose excursions, and act on central nervous system pathways to promote satiety and reduce appetite
Medication adjustments may be necessary in some cases, particularly if patients experience sustained significant heart rate increases
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