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Research has demonstrated a significant correlation between the severity of small airway disease and the degree of decline in forced expiratory volume in 1 second (FEV 1 ) ( 4.3.1 Core cell types and their roles Airway smooth muscle cells (ASMCs) act as the core cells of airway remodeling, exhibiting typical Warburg-like metabolism with abnormal proliferation highly dependent on aerobic glycolysis

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