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In some embodiments, formulations or compositions described herein provide a constant, sustained, extended, delayed or pulsatile rate of release of an active agent into the inner ear environment and thus avoid any variability in drug exposure in treatment of otic disorders

Do not use during pregnancy or breastfeeding

DarrasVVan HerckS

Resultant oxidative DNA base lesions have the potential to mutate some genetic material, which would impair the integrity of the genome by preventing transcription and replication and by generating mutagenesis (116)

Patients report mild to moderate soreness alleviated with Tylenol or ibuprofen

Still, side effects can occur