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Retatrutide is a triple agonist, meaning it also hits GIP and glucagon receptors on top of GLP-1

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Additionally, for individuals with type 2 diabetes, obesity, and heart failure with preserved ejection fraction, GLP-1 receptor agonists are advised to manage glucose and alleviate heart failure symptoms

There is no FDA-approved patch for a GLP-1, says Natasha Bhuyan, MD, a board-certified family physician at Amazon One Medical in Phoenix

In the periphery, GLP-1 is released from the gut in response to the presence of food nutrients

This means it works in the same way to slow down your digestive system, helping you lose weight by making you feel fuller for longer