Use is most often described after age-related collagen decline becomes visible, commonly from the mid-30s onward
Many people ignore it for years until symptoms become severe
Professional societies should provide clear guidance about when clinical diagnosis is appropriate and how to implement empirical treatment strategies

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B12 can hurt when injected to push the plunger slowly
This is based on its 6 to 8 day half-life and the pharmacological principle that 4 to 5 half-lives are required for near-complete elimination