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Others have shown in clonal INS-1 cells and primary hepatocytes that GLP-1(2836) increases cellular cAMP and phosphorylation of PKA, cAMP response elementbinding protein (CREB), cAMP-dependent transcription factor-1 (ATF-1), and -catenin (27, 41)
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10.1046/j.1523-1755.2001.0590031052.x 63 FyhrquistF.TiituA.SaijonmaaO.ForsblomC.GroopP
Disruptions in these processes contribute to disease severity and highlight potential therapeutic targets
References Rivier J, Spiess J, Thorner MO, Vale W
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