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Wilmes A, Bielow C, Ranninger C et al (2015) Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics

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It interacts with pathways like the nitric oxide (NO) system and can downregulate pro-inflammatory cytokines while protecting cells from oxidative stress

That said, if any adverse effect is suspected to be dose-related, the dose can be reduced

10.1053/jscd.2000.5869 116 SulzerD.ChenT