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Front Digit Health

JAM, junctional adhesion molecule

The medication works through a dual mechanism of action as both a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist and a glucagon-like peptide-1 (GLP-1) receptor agonist

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10.2903/j.efsa.2017.5058 57 WangZ.HanN.ZhaoK.LiY.ChiY.WangB

A 2025 Nature Medicine analysis of the SURMOUNT-1 trial showed that tirzepatide achieved similar 72-week weight reduction in carriers of pathogenic MC4R mutations (18.3%) and noncarriers (19.9%), suggesting preserved responsiveness in the most common form of monogenic obesity [137]