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While patients in the study achieved meaningful weight loss, individual results varied: The research group earlier documented two primary drivers that contributed to patients stopping their medication: cost or insurance coverage limitations and side effects, with the former being the dominant reason

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As soon as liver fat falls, metabolic health follows

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Other findings included: Gallbladder issues (especially with rapid weight loss) Pancreatitis (rare, with unclear causality) Thyroid C-cell hyperplasia (in animals, not seen in humans) Lean mass lossup to 40% of weight lost may be muscle in older adults None of these derailed regulatory approvals