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Tran MT, Son GH, Song YJ, Nguyen NT, Park S, Thach TV, Kim J, Sung YW, Das S, Pramanik D (2023) CRISPR-Cas9-based precise engineering of SlHyPRP1 protein towards multi-stress tolerance in tomato

Inhibition of MFG-E8 via shRNA transfection decreased phosphorylation levels of ERK1/2, Akt, and GSK-3 in the kidneys of db/db mice, improving renal histopathology

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Phase 1b PoC fully enrolled APG273APG273 / IL-13 + TSLP / combination of zumilokibart (APG777) + APG333 monoclonal antibodies / respiratory immunology and inflammationAsthma / COPDPreclinicalin-progress APG808APG808 / IL-4R / antibody / respiratory immunology and inflammationAsthmaPhase 1bpositive interim results announced May 2025 4assets BPL-003BPL-003 / Intranasal mebufotenin benzoate / Mental healthTreatment-resistant depressionPhase 2In development VLS-01VLS-01 / 5-HT1/2/6/7 receptor agonist / Oral transmucosal DMT buccal film / Mental healthTreatment-resistant depressionPhase 2In development EMP-01EMP-01 / Oral R-MDMA / Mental healthSocial anxiety disorderPhase 2Positive topline results announced Novel 5-HT2A Receptor Agonists5-HT2A receptor / Small-molecule neuroplastogens / Mental healthOpioid use disorderDiscoveryIn developmentTreatment-resistant depressionDiscoveryIn development 4assets DeramiocelCAP-1002 / allogeneic CDCs / Neuromuscular diseaseDuchenne muscular dystrophy (DMD)Phase 3in progressBecker muscular dystrophy (BMD)Preclinicalin progress StealthXSTX-S / Exosome-based vaccine / Infectious diseaseSARS-CoV-2Phase 1in progress StealthXTherapeutic ExosomesEvaluatingPreclinicalin progress CDC-ExosomesExosome Platform / Neuromuscular diseaseDuchenne muscular dystrophyPreclinicalin progress 4assets CLN-978CLN-978 / CD19xCD3 / bispecific T cell engager / ImmunologyOUTRACE: Rheumatoid arthritisPhase 1Initial data in RA in Q2 2026 and repeat dosing data in Q3 2026EuropeOUTRACE: Systemic lupus erythematosusPhase 1bInitial data in SLE in Q2 2026GlobalOUTRACE: Sjgrens diseasePhase 1Initial data in Sjgrens disease in Q4 2026Global VelinotamigBCMAxCD3 / bispecific T cell engager / ImmunologyAutoimmune diseasesIND-EnablingGenrix Bio initiated a Phase 1 study in China in Q4 2025