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US survey data from the NHANES What We Eat in America 2013e16 cohort reported the median vitamin B12 consumption for all adult men of 5.1 mcg and women of 3.5 mcg.95b Using the Estimated Average Requirement (EAR) for adults for Vitamin B12 of 2 mcg,93 less than 3% of men and 8% of women in the United States had inadequate diets using this comparator
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In animal-based models of depressive-like behavior, administration of the peptide was linked to attenuation of behavioral symptoms, indicating possible antidepressant-like activity under experimental conditions (25,26)
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