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Viral entry is blocked when PTEN, a PI3K/Akt pathway inhibitor, is overexpressed in target cells ( + T cells relative to uninfected or NL4.3Env infected primary CD4 + T cells ( Following entry, productive HIV-1 replication is also inhibited in primary CD4 + T cells when PI3K/Akt/mTOR signaling activity is decreased (Taylor et al., 2020)

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Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability

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