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[DOI] [PubMed] [Google Scholar] 52.Wang JY, Wen LL, Huang YN, Chen YT, Ku MC

Some research shows tissue healing benefits within a few days in small animal studies, while human research use may show improvements over 12 weeks

The risk may be lowered by a reduction in the dose of insulin secretagogues or insulin

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The magnitude varies significantly between individuals: STEP 4 Trial : Participants who stopped semaglutide after 20 weeks regained approximately 7% body weight over next 48 weeks (compared to losing an additional 8% who continued medication) Real-World Studies : Variable outcomes