System X c can be regulated at the transcriptional and post-transcriptional stages by various ferroptosis inducers, such as p53, erastin, sorafenib, sulfasalazine, and glutamate (Tobaben et al., 2011
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Insulin resistance: A 2012 study found that TB-500 ameliorates hyperglycemia and improves insulin resistance in a mouse model of type 2 diabetes mellitus (T2DM), indicating that it may be an alternative insulin sensitizer [7]
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These intermediates serve as important lipid attachments for the posttranslational modification of a variety of proteins, including the subunit of heterotrimeric G-proteins
