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Most community protocols use 3-6 cycles (one cycle = 3 days on, 4 days off) per course, with 3-6 months rest between courses

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In male mice, almost all renal biomarkers of inflammation were statistically significantly elevated (ALT, AST, BAP, MCP-1, IL-6, TNF-, and PAI-1), while in female mice only one biomarker was elevated (resistin)

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10.1016/j.theriogenology.2016.02.034 2