4 A history of gallbladder disease A 2022 systematic review of 76 randomised trials found that GLP-1 medications are associated with a relative risk of around 37% for gallbladder or biliary disease, with a higher relative risk in weight-loss trials than in diabetes trials
It may help improve cardiac function, reduce angina symptoms, and enhance exercise tolerance in individuals with heart conditions
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They also contribute to blood sugar spikes that counteract the glucose-regulating benefits of GLP-1 therapy