When redox homeostasis is disrupted, excess ROS compromise the integrity of DNA, RNA, and proteins, promoting mutations, chromosomal breaks, and, in extreme cases, cell death (He et al
Thus, structures of glutathionylated glutaredoxins 31,43,44,45 most likely resemble enzyme species F, whereas similar structures of complexes between reduced glutaredoxin and GSH with longer sulfursulfur distances 24,46 do not represent the interaction with GSH (but probably also resemble species F)
With cytochrome P-450, the substrate is jammed right up against the location where the oxo ligand must reside in the high-valent oxo intermediate
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Orv Hetil
This "delivery vehicle" mimics your body's natural structures, allowing the glutathione to be absorbed directly into the bloodstream and delivered to the cells that need it most