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Pacheco-Pantoja EL, Ranganath LR, Gallagher JA, Wilson PJ, Fraser WD

Sodhi M, Rezaeianzadeh R, Kezouh A, Etminan M

In a trial on tirzepatide, a once-weekly 15 mg dose resulted in a 20.9% reduction in body weight over 72 weeks compared to a weight reduction of 3.1% in the placebo group

cAMP accumulation assay Wild-type GLP-1R and GLP-1R mutants were cloned into the expression receptor pcDNA3.1/V5-His-TOPO vector (Invitrogen) at the HindIII and EcoRI sites by using the QuickChange site-directed mutagenesis and a flag-tag was inserted after native signal sequence (see primers in Supplementary Table 2)

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EdU proliferation assay A 5-ethynyl-20-deoxyuridine (EdU) incorporation assay kit (Ribobio, Guangzhou, China) was used to assess fibroblast proliferation