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In large randomized controlled trials, patients receiving semaglutide 2.4 mg lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28, Wissam Ghusn, MD, postdoctoral research fellow from the division of gastroenterology and hepatology of the Precision Medicine for Obesity Laboratory at Mayo Clinic in Rochester, Minnesota, and colleagues wrote

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The more pressing question is how GLP-1s should be used responsibly over time for weight loss, obesity, and reducing related health risks

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Taking them together helps keep glutathione in its active, free-radical-fighting state