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Injuries to certain tissues, such as tendons, "are very slow to heal" with conventional treatments, he says

The role of aldose reductase in polyol pathway: an emerging pharmacological target in diabetic complications and associated morbidities

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It is noteworthy that ORF3a has a TRAF-binding domain at the N terminus that can activate NF-B and the NLRP3 inflammasome 143 , suggesting an important role in the host immune response