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That basically means it is less likely to wipe out your gut flora to the extent that other antibiotics like Neomycin might

It can take up to a week, but normally they feel the benefits after a couple of days

When interpreted together with the findings of the STEP 4 withdrawal trial and STEP 1 off-treatment extension study, which both showed weight regain after semaglutide discontinuation (after 20 weeks treatment in STEP 4 and 68 weeks treatment in STEP 1) 23,24 , these results support the benefit of continued semaglutide treatment for sustained weight loss

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With more research and better understanding, the peptide rules might change to be safe, helpful, and accessible to those who can benefit from them