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These effects are processed by a specific sequence of neurotransmitters beginning within domains of the ARC that consist of orexigenic neurons expressing neuropeptide Y (NPY) and Agouti-related peptide (AgRP) as well as domains that consist of anorexigenic neurons expressing pro-opiomelanocortin, POMC (yielding the neurotransmitter -MSH) and cocaine and amphetamine-regulated transcript (CART)

For relative quantification, proteins with a fold change less than 2 or greater than +2, along with an adjusted p value corresponding to an FDR of 0.05, were considered differentially expressed

Nat Microbiol 10 , 30133025 (2025)