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In different germ-free (GF) animal models (mouse, pig) [64, 65], it was observed that the number of macrophages and neutrophils decreased, CD4+ and CD8+ cells decreased, Th1 /Th2 regulation imbalance, Th17 and TREG differentiation decreased, IgA level decreased and plasma cell number decreased [47]

pylori triggers ChaC1 overexpression in gastric epithelial cells, leading to GSH degradation and ROS accumulation, suppressing nucleotide alterations in TP53 that induce tumor suppressor gene expression (130)

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2023;48:E334E344

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