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Discontinuing semaglutide typically leads to weight regain over 1-2 years if lifestyle changes are not sustained, making it a long-term management tool rather than a temporary fix

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[8] The most dangerous interactions are with drugs that affect serotonin levels: this includes many antidepressants (SSRIs like Prozac, SNRIs like Effexor, tricyclics, MAO inhibitors), as well as others like certain migraine medications (triptans), St

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Specific populations requiring additional caution include individuals with renal impairment, myasthenia gravis, heart block, or bowel obstruction