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11 A systematic review employing the PICO (Population or Patient, Intervention, Comparison, Outcome) and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) frameworks analyzed literature published between July 5, 2021, and March 13, 2022, to assess region-specific prevalence rates of PACS

These findings are intriguing yet still incomplete

In the past few decades, drug therapy for T2DM has developed greatly and involves several new strategies [20,21,22]

Oxidative stress can disrupt these tolerance mechanisms by inducing apoptosis of regulatory T cells (Tregs), which are critical for maintaining immune homeostasis and preventing autoimmunity [141]

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