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The C20 fatty diacid moiety is attached to a lysine residue at position 20 via a gamma-glutamate and bis-aminodiethoxyacetyl linker, providing high affinity for albumin binding that prolongs circulating half-life

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Cysteine deprivation is linked to ferroptosis, a non-apoptotic form of cell death that involves lipid peroxidation 31

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Spinner RJ, Desy NM, Amrami KK