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Semaglutide, a type of GLP-1 glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonists or GLP-1 RAs), has gained awareness for its role in managing type 2 diabetes and promoting weight loss in some individuals

doi: 10.1016/j.resmic.2018.09.002 42 CorrieLAwasthiAKaurJVishwasSGulatiMKaurIPet al

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However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]

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