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Introduction Carnosine is a histidine-containing dipeptide formed by beta-alanine (BA) and L-histidine that is abundant in human skeletal muscle ( + ) buffering ( + accumulation and can be improved by increasing buffering capacity ( Beta-alanine is a non-proteogenic amino acid and the limiting factor for carnosine formation in the skeletal muscle ( Muscle Carnosine Metabolism Carnosine homeostasis is dependent on its synthesis from, and degradation to, its constituent amino acids

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