what happens if you take a double dose of semaglutide Dosage Chart for Weight Loss & Dosing Guide Accidental Double Dose of Semaglutide:

So I get that we're hacking kind of that hormonal side of the metabolic adaptation, or at least one aspect of that hormonal

Some patients may show a decreased responsiveness, others a shortened duration of effect

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The main difference was that Exenatide 2.0mg [2.07% (95% CI: 2.93%, 1.22%)] was more effective in lowering fasting blood glucose, followed by Semaglutide 2.0mg and Semaglutide 1.0mg [2.51% (95%) CI: 3.00%, 2.02%)]

Most human DSIP studies are more than 30 years old and were conducted before many modern clinical-trial standards became routine