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Because they are not easily cleared, very high intakes can build up and cause toxicity

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

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Why the Gastric and Central Effects Can Come Apart A subtle but important idea underlies much of this article: amylins slowing of gastric emptying and its suppression of appetite are related but separable, and they may not rise and fall together under a long-acting drug

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