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In glioma cells, the action of metformin involves activating AMPK, inhibiting cell growth and metabolism, thereby suppressing tumor development [32, 45, 46]

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Oftentimes, when doing pull-down experiments, researchers will include a control experiment using GST alone instead of their GST-fusion protein

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

Lipid peroxidation products role in autophagy regulation

Notably, clinical observations indicate that endocrine therapy resistance is closely associated with oestrogen-dependent redox signal dysregulation mediated by ROS, suggesting that targeting ROS homeostasis may represent a novel breakthrough for reversing drug resistance [127]