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These changes result from the direct effect of GLP-1RAs on proinflammatory cytokines production in monocytes/macrophages as it blocks NF-B, and lowers the formation of pro-inflammatory M1 macrophages

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Analyst views range from conservative to aggressive: Piper Sandler estimates 20-30 basis points of impact on confectionery and salty snacks, while the broader $48 billion spending reduction forecast suggests significantly steeper headwinds for certain categories. The restaurant collapse nobodys talking about Fast-food and limited-service restaurant spending has declined 8% among GLP-1 users, with 54% of GLP-1 users reporting they dine out significantly less or less frequently since starting medication

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