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Some people carry genetic variants that increase their headache risk during the first month of treatment, while others are naturally resilient

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Meta-analysis of results reported from SURPASS-1 to -5 clinical trials regarding achievement of HbA 1c targets

Women of childbearing potential should be advised that tirzepatide may reduce the effectiveness of oral contraceptives, particularly during dose initiation and escalation periods, and should consider using non-oral or additional contraceptive methods

Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF

For constipation, increasing fibre, fluids, and physical activity may help