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When joint cartilage or surrounding tissues are injured, endogenous molecules such as damage-associated molecular patterns (DAMPs), are released into the extracellular environment [13]

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Of particular promise, nanoparticles can insulate their contents from external biochemical injury [11]

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Consequently, the inhibitory ability of the modified peptide was enhanced by approximately three-fold compared to that of p53 TAD PEP (Figure