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The AGA and ACG provide evidence-based guidelines emphasizing treat-to-target strategies, with objective monitoring through endoscopy, cross-sectional imaging, and biomarkers (C-reactive protein, fecal calprotectin) to assess mucosal healing and optimize outcomes

Emerging clinical observations suggest GLP-1s may influence gastrointestinal motility and immune signaling in ways that warrant careful provider evaluation before starting therapy

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However, despite the well-documented benefits of lifestyle changes, maintaining long-term adherence remains a challenge for many individuals, often requiring multidisciplinary support and long-term behaviour change strategies

Unlike serotonergic antidepressants such as sertraline and paroxetine, which can promote weight gain and potentially counteract GLP-1 agonist effects, bupropion is weight-neutral to slightly weight-loss promoting