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doi: 10.1007/s11695-022-06328 54 Le RouxCWBorgCWallisKVincentRPBueterMGoodladRet al

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Obesity is the root cause of many chronic diseases including cardiovascular disease, the number one killer, but also diabetes, liver and kidney disease

In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42

Multiple epidemiological studies link elevated IGF-1 levels to increased prostate and colorectal cancer risk