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The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability resulting in approximately three times greater potency than IGF-1, with a significantly longer half-life of about 2030 hours relative to IGF-1s half-life of about 1215 hours

The concept of a 'stack' combining two or more pharmacologically active compounds to achieve synergistic effects originates largely from bodybuilding and performance-enhancement communities

In multiple tendon and ligament healing models, BPC-157's therapeutic effects plateaued within the standard dose range, with higher doses producing no additional benefit 18